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A 35-year-old female complains to her doctor that she is suffering from frequent urination
A 35-year-old female complains to her doctor that she is suffering from frequent
urination. Her resting blood pressure and heart rate are 120/80 and 72, respectively.
Her plasma creatinine is 0.85 mg/dl, urine flow is 5 ml/min, and urine osmolarity is
190 mOsm/l. Her plasma osmolarity is 290 mOsm/l. Calculate her osmolar clearance
and free water clearance. Is her urine dilute or concentrated?
Expert Solution
Osmolar clearance
1 osmolar = 1 osmol / liter
OsmCl = (Urine_Osm / Serum_Osm) * Urine_Per_Day / 24
Free water clearance
The urine flow rate can be considered to be composed of two clearances. A clearance of isotonic solutes and a clearance of pure water.
V = Cosm + CH2O
For details, please see the attached file.
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