What is Paclitaxel mechanism of action? What are the indications for Paclitaxel? What is true of 10% of patient with the use of Paclitaxel? What are the major limiting toxicities of Paclitaxel/ what is the prototype topomirase 1 inhibitor? What is the prototype topoisomerase 2 inhibitor? What is the action of a topoimerase? What is the effect of blocking topoimerases? What phase of the cycle to topoisomerase effectively block? What are the limiting toxicities of Toptecan?

1. What is Paclitaxel mechanism of action?

creates unusually stable tubulin molecules that stack and fail to depolymerize so the stell stays frozen in metaphase

2. What are the indications for Paclitaxel?

ovarian and breast cancer through the IV

3. What is true of 10% of patient with the use of Paclitaxel?

they need to pretreated with corticosteroids and antihistamines to prevent anaphylazxis due to hypersenstivity with diluents

4. What are the major limiting toxicities of Paclitaxel/

BMS and neurotoxicity

5. what is the prototype topomirase 1 inhibitor?

Topotecan

6. What is the prototype topoisomerase 2 inhibitor?

Etoposide

7. What is the action of a topoimerase?

enzymes that break and then re-anneal DNA in order to allow it to unwind, so that it may be replicated and repaired -- Type 1 - only cuts one strand of DNA and Type 2 - cuts both strands of DNA

8. What is the effect of blocking topoimerases?

leads to DNA breaks that are not repaired causing cell death

9. What phase of the cycle to topoisomerase effectively block?

S and G2 phase of the cell cycle

10. What are the limiting toxicities of Toptecan?

BMS and thrombocytopenia (avoid infections and cuts in patients)