How does palliative care occur? What is curative chemotherapy like with solid tumors? What are the effects of curatice chemotherapy like on disseminated tumors? What is the factor that minimizes the maximum dose that can be given to a person? and the drugs that are combined? What drug counters neutropenia? What cells do the toxicities generally target? What are the side/adverse effects of the general chemotherapeutic agents? What are the effects of bone marrow supression? Why do drugs develop resistance? How is multidrug resistance formed in cancer cells?

1. How does palliative care occur?

the tumor gets to this point by either being detected too late to be controlled, or due to the constant exposure of the cancers cells to therapies resulting in the overall

2. What is curative chemotherapy like with solid tumors?

tumor burden is intially reduced by surgery or radiation, treatment of occult micrometastases is continued after clinical signs of cancer cancer have disappeared

3. What are the effects of curatice chemotherapy like on disseminated tumors?

combination drug therapy reduces the change of drug resistance, each drug is chosen to have a different cellular site of action or different cell cycle specificity, or organ toxicity

4. What is the factor that minimizes the maximum dose that can be given to a person? and the drugs that are combined?

for each drug used to treat cancer, there is usually a small group of toxicities that limit the maximum dose -- try to limit overlapping toxicities when using the multiple drugs

5. What drug counters neutropenia?

Filgrastim

6. What cells do the toxicities generally target?

Those cells that are rapidly dividing

7. What are the side/adverse effects of the general chemotherapeutic agents?

Alopecia (hair loss), stomatitis (inflammation of the mouth), GI problems, Bone Marrow Suppression (BMS) and cardiotoxicity

8. What are the effects of bone marrow supression?

leukopenia, thrombocytopenia, anemia

9. Why do drugs develop resistance?

some cancers can be inherently resistant to certain drugs, others can be repeatedly exposed to the drug and develop resistance this

10. How is multidrug resistance formed in cancer cells?

a gene product called P-glycoprotein pumps create multiple drugs out of cells - found in all ells, but increase in cancer cells