What is the development of a cancer neoplasm? What are the oncongenes? What is cell dedifferentiation? What is the growth pattern of the early tumor? What is metastasis? What is the difference between a distinct localized tumor or disseminated tumor? What is the flow of the cell cycle? What happens during Go phase of the cell cycle? What happens during G1 phase of a cell cycle? What occurs during the S phase of the cell cycle?

1. What is the development of a cancer neoplasm?

exposure to mutating influence --> activation of cellular oncongene -> dedifferentiation -> early tumor development -> metastasis -> secondary tymor

2. What are the oncongenes?

genes that play a role in controlling division process - if there in the on position or mutation there - leads to predisposition of cancer

3. What is cell dedifferentiation?

primary tumor -- cells develop embryonic characteristics

4. What is the growth pattern of the early tumor?

logarithmic growth (tumor grows faster and then reaches a plateau) -- gompertzian growth

5. What is metastasis?

have to put growth factors that initiate the spread of vasculature into the tumor (avoid death in center); cells get into the blood stream and spread elsewhere

6. What is the difference between a distinct localized tumor or disseminated tumor?

distinction between cancer that produces a solid tumor and a disseminated cancer (leukemia) that is not localized

7. What is the flow of the cell cycle?

Go -> G1 -> S -> G2 -> M

8. What happens during Go phase of the cell cycle?

resting phase, no cell division or DNA replication

9. What happens during G1 phase of a cell cycle?

presynthesis phase, protein biosynthesis, needed for DNA synthesis

10. What occurs during the S phase of the cell cycle?

synthesis of DNA, most sensitive part of cell cycle-- because DNA is essential to the cell division