What is the pharmacokinetics of the glinides? What is the general indication for glinides? What is the indicationn for glinides and why? What are the drug - drug of glinides? Who are glinides contraindicated in? What are the adverse reactions of the glinides? What are the drug drug interactions of the glinides? What is the dosing of glinides like? What is the action of thiazolidinediones? What is the prototype Thiazolidinediones/

1. What is the pharmacokinetics of the glinides?

rapidly abosorbed, act within a few minutes, then quickly metabolized by the liver, and excreted in the bile

2. What is the general indication for glinides?

take just before meals to make insulin more available reducing post prandial rise in blood glucose without the danger of hypoglycemia in between meals

3. What is the indicationn for glinides and why?

Type II d. who want a flexible lifestyle of unplanned eating behavior (geriatric) or when other antidiabetic drugs fail to work due to the quick elimination

4. What are the drug - drug of glinides?

act synergystically with metformin and thiazolidinediones and can be combined with long-acting insulin (NPH at bedtime)

5. Who are glinides contraindicated in?

pregnancy and lactation

6. What are the adverse reactions of the glinides?

hypoglycemia

7. What are the drug drug interactions of the glinides?

NSAIDS, salicylates and non-selective b-blockers

8. What is the dosing of glinides like?

take before meals and major snacks, but skip a meal and skip a dose

9. What is the action of thiazolidinediones?

acts ans an insulin sesitizer and decreases the production of glucose from the liver, and reqiures insulin in the body to work

10. What is the prototype Thiazolidinediones/

Rosiglitazone