who is odansteron indicated for? When should odansteron be administered? what are other drugs that are used to block vomiting? What is true of antiemetic agents? What is the indication for Ipecac? What type of pt should never be given Ipecac? What are the adverse uses of ipecac? What is the prototype GI stimulant? What is the indication for metoclopromide? What is the mechanism of action of metoclopromide?

1. who is odansteron indicated for?

block vomiting with chemotherapy, radiation and surgeries

2. When should odansteron be administered?

before nausea and vomiting because it is harder to stop once they occur -- 30 min b4 treatment

3. what are other drugs that are used to block vomiting?

Scopolamine (muscarinic antagonist), marijuana derived drugs (dronabinol), corticosteroids, anithistmaind, droperidol, and benzos

4. What is true of antiemetic agents?

They are better when used in combination v. a single drug

5. What is the indication for Ipecac?

for overdose or poisoning situations because it induces vomiting (no longer recommended since 2003)

6. What type of pt should never be given Ipecac?

unconscious patient and those with depressed gag/cough reflexes (no control over the epiglottis), patients who have swallowed corrosive substances

7. What are the adverse uses of ipecac?

eating disorders, overuse can lead to cardiomyopathy, ventricullar fibrilation and death

8. What is the prototype GI stimulant?

Metoclopromide (reglan)

9. What is the indication for metoclopromide?

diabetic gastroparesis, GERD, used for nausea and vomiting (off label)

10. What is the mechanism of action of metoclopromide?

blocks dopamine and 5HT receptors in CTZ -- enhances cholinergic effects on GI