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Jennifer is stable on the antihypertensive agent, drug B

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Jennifer is stable on the antihypertensive agent, drug B. Drug C,a drug for osteoarthritis is known to reduce the absorption of drug C when given concurrently although the mechanism of the interaction is not clear. This interaction lowers the concentration of drug B at its receptors. After adding drug C to her regimen Jennifer's blood pressure becomes less well controlled and you now need to increase the dose of drug B to overcome the effects of the interactions. This is an example of _____________.


Drug deposition tolerance
Drug resistance
Pharmacodynamic tolerance
Tachyphylaxis